Table 1.
The family of matrix metalloproteinases (MMPs), tissue distribution, and substrates.
| SUBFAMILY | MMP | Tissue Distribution | Substrates |
|---|---|---|---|
| Collagenases | |||
| Collagenase-1 | MMP-1 | Endothelial cells, VSMCs, vascular wall, platelets, fibroblasts, macrophages | Collagens: I, II, III, VII, VIII, X Gelatins, entactin, aggrecan, link protein |
| Collagenase-2 | MMP-8 | Macrophages, neutrophils | Collagens: I, II, III; Aggrecan link protein |
| Collagenase-3 | MMP-13 | Vascular wall, SMCs, macrophages | Collagens: I, II, III |
| Gelatinases | |||
| Gelatinase-A | MMP-2 | Endothelial cells, VSMCs, adventitia, leukocytes, dermal fibroblasts, platelets | Collagens: I, IV, V, VII, X, XI; Gelatins, elastin, fibronectin, laminin, b-amyloid protein precursor |
| Gelatinase-B | MMP-9 | Endothelial cells, VSMCs, adventitia, vascular wall, macrophages | Collagens: IV, V, XIV; Gelatins, elastin, entactin, vitronectin |
| Stromelysins | |||
| Stromelysin-1 | MMP-3 | Endothelial cells, VSMCs, vascular wall, platelets | Collagens: III, IV, IX, X; Aggrecan, fibronectin, laminin, elastin, gelatins, casein |
| Stromelysin-2 | MMP-10 | Uterus | Collagens: II, IV, V; Aggrecan, fibronectin, gelatins, activate procollagenase |
| Stromelysin-3 | MMP-11 | Uterus, brain | Collagen IV, weakly fibronectin, laminin, aggrecan, gelatins, IGFBP-1, a1-protease inhibitor |
| Matrilysins | |||
| Matrilysin-1 | MMP-7 | Endothelial cells, VSMCs, vascular wall, uterus | Collagen IV, aggrecan fibronectin, laminin, entactin, vitronectin, casein, IGFBP-1 |
| Matrilysin-2 | MMP-26 | Collagen IV, gelatin, fibronectin |
|
| Membrane-type MMPs | |||
| MT1-MMP | MMP-14 | Vascular wall, platelets, fibroblasts, uterus, brain | Collagens I, II, III; fibronectin, laminin-1, dermatan sulfate |
| MT2-MMP | MMP-15 | Fibroblasts, leukocytes | Large tenascin-C, fibronectin, laminin, entactin, aggrecan, perlecan |
| MT3-MMP | MMP-16 | Vascular wall, leukocytes | Collagen III, gelatin, casein, fibronectin |
| MT4-MMP | MMP-17 | Brain | Activates MMP2 by cleavage |
| MT5-MMP | MMP-24 | Leukocytes, lung, pancreas, kidney, brain | Activates MMP2 by cleavage |
| MT6-MMP | MMP-25 | Leukocytes | Inactivates alpha-1 proteinase inhibitor |
| Other | |||
| Metalloelastase | MMP-12 | VSMCs, fibroblasts, macrophages, great saphenous vein | Elastin, fibronectin |
| RASI-1 | MMP-19 | Liver | Gelatin |
| Enamelysin | MMP-20 | Tooth enamel | Amelogenin |
| Xenopus-MMP | MMP-21 | Fibroblasts, macrophages, placenta | |
| CA-MMP | MMP-23 | Ovary, testis | Gelatin |
| Epilysin | MMP-28 | Skin, keratinocytes | Casein |