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. 2020 May 30;21(11):3902. doi: 10.3390/ijms21113902

Figure 1.

Figure 1

Serum estradiol concentrations and bladder, kidney, and urethra metrics in control (CTL-), BPA-, or DES-treated mice, without (0, light bars) and with (TE2, dark bars) adult treatment. (A) Serum estradiol concentrations and (B) incidence of bladder and kidney abnormalities observed at the time of necropsy. (C) Examples of bladder size using the observational grading scale. (D) Bladder size based on observational grading (left) or on volume calculated from external dimensions (right) in fixed tissues. (E) CT measurements of bladder wall thickness and post-prostatic urethra wall thickness in fixed tissues. Values are mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001 vs. CTL-0; ✫ P < 0.05 vs. CTL-TE2.