Table 1.
Demographic and clinical features of probable MSA-P and MSA-C patients
| Demographic and clinical parameters | Overall (n=45) | MSA-P (n1=22) | MSA-C (n2=23) | Test statistic | P |
|---|---|---|---|---|---|
| Age in years# (mean±SD) | 55.69±8.09 | 57.23±8.67 | 54.22±7.39 | 0.71 | 0.494 |
| Age of onset of disease in years# (mean±SD) | 53.27±8.25 | 54.68±8.98 | 51.91±7.42 | 1.12 | 0.265 |
| Disease duration in years$ [median (IQR)] | 2 (1.5) | 2 (1.6) | 2 (1.5) | 153 | 0.78 |
| Gender | |||||
| Male [n (%)]@ | 31 (68.9) | 12 (54.5) | 19 (82.6) | 4.13 | 0.127 |
| Female [n (%)]@ | 14 (13.11) | 10 (45.5) | 4 (17.4) | ||
| Parkinsonian features | |||||
| Tremor [n (%)]@ | 25 (55.6) | 15 (68.2) | 10 (43.5) | 2.78 | 0.095 |
| Rigidity [n (%)]@ | 38 (84.4) | 21 (95.5) | 17 (73.9) | 3.97 | 0.046* |
| Bradykinesia [n (%)]@ | 35 (77.8) | 21 (95.5) | 14 (60.9) | 7.78 | 0.005** |
| Stooped posture [n (%)]@ | 8 (17.8) | 7 (31.8) | 1 (4.3) | 5.8 | 0.02* |
| Postural Instability [n (%)]@ | 8 (17.8) | 5 (22.7) | 3 (13) | 0.72 | 0.39 |
| Freezing of gait [n (%)]@ | 7 (15.6) | 7 (31.8) | 0 (0) | 8.66 | 0.003** |
| Cerebellar features | |||||
| Ataxic gait [n (%)]@ | 14 (31.1) | 3 (13.6) | 11 (47.8) | 6.13 | 0.013* |
| Finger nose incoordination [n (%)]@ | 24 (53.3) | 3 (13.6) | 21 (91.3) | 27.25 | <0.001*** |
| Knee-Heel-Shin Incoordination [n (%)]@ | 22 (48.9) | 2 (9.1) | 20 (87) | 27.28 | <0.001*** |
| Dysdiadochokinesia [n (%)]@ | 20 (44.4) | 3 (13.6) | 17 (73.9) | 16.54 | <0.001*** |
| Impaired tandem gait [n (%)]@ | 21 (46.7) | 3 (13.6) | 18 (78.3) | 18.86 | <0.001*** |
| Dysarthria [n (%)]@ | 28 (62.2) | 12 (54.5) | 16 (69.6) | 1.08 | 0.299 |
| Up-gaze restriction [n (%)]@ | 16 (35.6) | 11 (50) | 5 (21.7) | 3.92 | 0.048* |
| Down-gaze restriction [n (%)]@ | 3 (6.7) | 2 (9.1) | 1 (4.3) | 0.41 | 0.608 |
| Lateral gaze restriction [n (%)]@ | 1 (2.2) | 0 (0) | 1 (4.3) | 0.98 | 0.323 |
| Slow saccades [n (%)]@ | 7 (15.6) | 4 (18.2) | 3 (13) | 0.23 | 0.634 |
| Jerky pursuit [n (%)]@ | 3 (6.7) | 2 (9.1) | 1 (4.3) | 0.41 | 0.608 |
| Vertical gaze evoked nystagmus [n (%)]@ | 1 (2.2) | 1 (4.5) | 0 (0) | 1.07 | 0.489 |
| Horizontal gaze evoked nystagmus [n (%)]@ | 6 (13.3) | 2 (9.1) | 4 (17.4) | 0.67 | 0.665 |
| Falls [n (%)]@ | 24 (53.3) | 15 (68.2) | 9 (39.1) | 3.81 | 0.051 |
| Cardiac dysautonomia features | |||||
| Postural dizziness/orthostatism [n (%)]@ | 25 (55.6) | 10 (45.5) | 15 (65.2) | 1.78 | 0.236 |
| Orthostatic hypotension [n (%)] @ | 22 (48.9) | 10 (45.5) | 12 (52.2) | 0.20 | 0.768 |
| Δ↓Systolic BP in mmHg [Median (IQR)]$ | 23 (25) | 25 (30) | 23 (17) | 112 | 0.752 |
| Δ↓Diastolic BP in mmHg [Median (IQR)]$ | 12 (19) | 12 (21) | 14 (21) | 97 | 0.519 |
| Urogenital features | |||||
| Bladder disturbances [n (%)]@ | 35 (77.7) | 19 (86.36) | 16 (69.56) | 3.74 | 0.053 |
| Erectile dysfunction [n (%)]@ | 9 (20) | 2 (9.1) | 7 (30.4) | 3.20 | 0.074 |
| REM behavior disorder (RBD) | |||||
| RBD present [n (%)]@ | 19 (42.2) | 8 (36.4) | 11 (47.8) | 0.61 | 0.436 |
| Duration of RBD in years (Mean±SD)# | 3.11±2.58 | 4.4±3.36 | 2.31±1.75 | 1.48 | 0.165 |
MSA=multiple system atrophy; MSA-P=parkinsonian variant; MSA-C=cerebellar variant; SD=standard deviation; IQR=interquartile range. #Independent samples “t” test, $Mann-Whitney U-test,@Pearson’s Chi-square/Fisher’s exact test, *P<0.05, **P<0.01, ***P<0.001