TABLE 2.

Overview of the most used animal models of PD, their associated phenotypes and AS pathology.

Model	Type	Motor phenotype	Non-motor phenotype	Animal	αS/Lewy pathology
Toxin-induced	Rotenone	✓	✓	Mouse, rat	Yes
	MPTP	✓	✓	Mouse, primate	No
	6-OHDA	✓	✓	Rat	No
	Paraquat	✓	✓	Mouse	Yes
Genetic	αS overexpressing	✓	✓	Mouse	Yes
	αS-A53T transgenic	Not consistent	✓	Mouse	Yes
	Pink1	–	✓	Mouse	No
	MitoPark	✓	✓	Mouse	No
Propagation	αS PFF	✓	✓	Mouse	Yes

αS, α Synuclein; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 6-OHDA, 6-hydroxydopamine, PFF, recombinant αS preformed fibrils.