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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 May 23;1867(9):118746. doi: 10.1016/j.bbamcr.2020.118746

Figure 3: Potential signaling pathway underlying reconsolidation of stimulant-associated contextual memories.

Figure 3:

Activation of NMDA receptors in the nucleus accumbens and hippocampus following the reactivation of cocaine-contextual memories stimulates a protein phosphatase cascade, through PP2B and PP1, resulting in dephosphorylation of Akt and GSK-3β. GSK-3β can regulate mTORC1 and CREB. Arrows indicate changes in enzyme activity following reactivation of cocaine-associated memories. GSK, glycogen synthase kinase; mTORC1, mammalian target of rapamycin complex 1; PI3K, phosphatidylinositol 3-kinase; PP1, protein phosphatase 1; PP2B, protein phosphatase 2B. CREB, cAMP response element-binding protein. Adapted from Shi et al., 2014 & 2019b.