Table 3. Significantly altered proteins after the incubation of HK-2 cells with HG-Hypoxia in comparison to NG-Normoxia for 5, 24 and 48 h.
| 5 h | 24 h | 48 h | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene name | log2FC | N° samples | p-value | log2FC | N° samples | p-value | log2FC | N° samples | p-value |
| AKR1B1 | -0.13 | 6 | 1.9E-03 | 0.27 | 6 | 1.2E-02 | 0.52 | 6 | 2.0E-03 |
| ALDOA | -0.01 | 6 | 5.7E-01 | 0.25 | 6 | 1.2E-05 | 0.45 | 6 | 4.9E-04 |
| ATP5B | -0.10 | 6 | 2.7E-01 | -0.12 | 6 | 9.4E-02 | -0.29 | 6 | 2.2E-02 |
| CNN2 | -0.11 | 6 | 1.8E-01 | -0.27 | 6 | 1.2E-03 | -0.46 | 2 | 3.6E-01 |
| EZR | 0.03 | 6 | 5.7E-01 | 0.08 | 6 | 1.3E-01 | 0.36 | 6 | 6.8E-04 |
| FN1 | -0.03 | 6 | 2.6E-01 | -0.65 | 6 | 5.9E-04 | -0.92 | 6 | 6.7E-07 |
| FUS | -0.02 | 6 | 6.4E-01 | -0.02 | 6 | 4.6E-01 | 0.30 | 5 | 1.3E-03 |
| GAPDH | -0.01 | 6 | 7.4E-01 | 0.07 | 6 | 1.1E-01 | 0.27 | 6 | 1.1E-02 |
| GPI | -0.09 | 6 | 7.5E-02 | 0.28 | 6 | 5.0E-03 | 0.46 | 5 | 2.7E-03 |
| HIST1H1B | 0.03 | 6 | 5.7E-01 | -0.09 | 6 | 2.3E-01 | -0.49 | 5 | 1.1E-02 |
| HIST1H3A | 0.58 | 6 | 4.7E-02 | -0.11 | 6 | 2.5E-01 | -0.66 | 6 | 1.1E-03 |
| HIST1H4A | 0.60 | 6 | 4.0E-02 | -0.11 | 6 | 1.7E-01 | -0.57 | 6 | 9.7E-03 |
| HSPA1B | 0.22 | 6 | 4.1E-04 | 0.23 | 6 | 1.6E-04 | 0.37 | 6 | 4.0E-04 |
| HSPH1 | -0.08 | 2 | 2.7E-01 | 0.53 | 2 | 1.3E-01 | 0.75 | 4 | 2.7E-04 |
| LDHA | -0.01 | 6 | 9.1E-01 | 0.43 | 6 | 1.5E-05 | 0.85 | 6 | 1.5E-05 |
| PGAM1 | -0.01 | 6 | 7.0E-01 | 0.18 | 6 | 4.0E-03 | 0.40 | 6 | 5.0E-04 |
| PGK1 | -0.04 | 6 | 2.0E-01 | 0.23 | 6 | 7.0E-05 | 0.60 | 6 | 4.0E-05 |
| PKM | -0.03 | 6 | 1.3E-01 | 0.12 | 6 | 2.2E-03 | 0.28 | 6 | 2.9E-03 |
| PSME1 | 0.03 | 6 | 7.2E-01 | -0.10 | 6 | 5.3E-02 | -0.29 | 4 | 1.5E-02 |
| RPL18 | -0.30 | 6 | 6.3E-03 | -0.22 | 6 | 3.9E-02 | 0.02 | 5 | 7.4E-01 |
| RPL28 | -0.30 | 2 | 1.4E-01 | -0.40 | 6 | 7.6E-03 | -0.37 | 5 | 1.2E-01 |
| RPL34 | -0.34 | 6 | 2.0E-04 | -0.14 | 6 | 3.3E-02 | -0.01 | 6 | 9.0E-01 |
| RPS27 | 0.10 | 6 | 4.4E-01 | -0.36 | 4 | 3.4E-02 | -0.04 | 3 | 8.8E-01 |
| RTN4 | -0.01 | 6 | 8.6E-01 | 0.14 | 6 | 1.2E-01 | 0.37 | 5 | 1.7E-02 |
| S100A6 | 0.01 | 6 | 9.1E-01 | -0.18 | 6 | 7.6E-02 | -0.30 | 6 | 1.5E-05 |
| SLC25A5 | 0.15 | 6 | 1.4E-02 | -0.03 | 6 | 5.5E-01 | -0.33 | 6 | 8.9E-03 |
| STAT1 | 0.05 | 6 | 1.8E-02 | -0.29 | 6 | 9.0E-04 | -0.79 | 6 | 1.4E-06 |
| STMN1 | -0.14 | 6 | 1.7E-01 | -0.26 | 6 | 4.7E-04 | -0.70 | 6 | 4.3E-03 |
| TMSB4X | 0.09 | 6 | 5.8E-01 | -0.18 | 6 | 2.2E-02 | -0.40 | 6 | 1.7E-03 |
| TPI1 | -0.05 | 6 | 8.7E-02 | 0.21 | 6 | 9.6E-06 | 0.35 | 6 | 4.0E-04 |
| TPM1 | -0.13 | 6 | 1.2E-01 | -0.90 | 4 | 7.8E-06 | - | - | - |
| TPM4 | -0.05 | 6 | 4.8E-01 | -0.10 | 6 | 1.5E-01 | -0.31 | 6 | 3.9E-02 |
| TUBB | -0.15 | 6 | 5.9E-03 | -0.24 | 6 | 5.2E-03 | -0.29 | 6 | 1.0E-03 |
| UBA52 | -0.14 | 6 | 5.2E-02 | -0.33 | 6 | 6.7E-04 | -0.13 | 6 | 3.8E-02 |
* In grey, significantly altered proteins.