Day	Case 1	Case 2	Case 3
0	Presented to ED with 1 week of dyspnoea on exertion, orthopnoea, and cough	Presented to the ED with fevers	Presented to the ED with diarrhoea, myalgias, and dyspnoea; subsequently intubated
4–6	Echocardiogram revealed large pericardial effusion with signs of right ventricular dysfunction consistent with Takotsubo morphology Pericardiocentesis with drain placement	Hypoxaemic cardiac arrest and was intubated New ST elevation with PR depression in inferior leads, loss of precordial R waves	Tachycardic and in shock with reduced cardiac index (1.9 L/min/m2), improved with paralysis and proning Echocardiogram revealed basal-mid hypokinesis consistent with reverse Takotsubo morphology
7–10	Serial echocardiograms revealed resolution of effusion but new periapical wall motion hypokinesis, pericardial drain removed and discharged	Worsening respiratory and renal function; hypoxaemic pulseless electrical activity arrest and died	Developed septic shock with worsening respiratory failure leading to cardiopulmonary arrest and death
21	Echocardiogram demonstrated resolution of effusion and wall motion abnormalities