Table 2.
Changes in oncological therapy for esophageal cancer among respondents stratified in round 1 (n = 234) and 2 (n = 184) of the survey
| Standard | Round 1 | Round 2 | P-value | ||
|---|---|---|---|---|---|
| Esophageal adenocarcinoma | |||||
| Definitive chemoradiotherapy | No | 199 (85.0) | 141 (60.3) | 114 (62.0) | <0.001 |
| Yes | 35 (15.0) | 93 (39.7) | 70 (38.0) | ||
| Neoadjuvant chemoradiotherapy | No | 82 (35.0) | 124 (53.0) | 69 (37.5) | <0.001 |
| Yes | 152 (65.0) | 110 (47.0) | 115 (62.5) | ||
| Neoadjuvant chemotherapy | No | 73 (31.2) | 116 (49.6) | 60 (32.6) | <0.001 |
| Yes | 161 (68.8) | 118 (50.4) | 124 (67.4) | ||
| Surgery only | No | 161 (68.8) | 162 (69.2) | 109 (59.2) | 0.059 |
| Yes | 73 (31.2) | 72 (30.8) | 75 (40.8) | ||
| Esophageal squamous cell carcinoma | |||||
| Definitive chemoradiotherapy | No | 124 (53.0) | 83 (35.5) | 48 (26.1) | <0.001 |
| Yes | 110 (47.0) | 151 (64.5) | 136 (73.9) | ||
| Neoadjuvant chemoradiotherapy | No | 46 (19.7) | 130 (55.6) | 70 (38.0) | <0.001 |
| Yes | 188 (80.3) | 104 (44.4) | 114 (62.0) | ||
| Neoadjuvant chemotherapy | No | 180 (76.9) | 193 (82.5) | 141 (76.6) | 0.2 |
| Yes | 54 (23.1) | 41 (17.5) | 43 (23.4) | ||
| Surgery only | No | 181 (77.4) | 189 (80.8) | 140 (76.1) | 0.5 |
| Yes | 53 (22.6) | 45 (19.2) | 44 (23.9) | ||
| Radical radiotherapy | No | 213 (91.0) | 197 (84.2) | 142 (77.2) | <0.001 |
| Yes | 21 (9.0) | 37 (15.8) | 42 (22.8) | ||
| Timing of surgery after neoadjuvant therapy | |||||
| <6 weeks | 59 (25.2) | 24 (10.3) | 24 (13.0) | <0.001 | |
| 6–8 weeks | 132 (56.4) | 46 (19.7) | 69 (37.5) | ||
| 8–10 weeks | 30 (12.8) | 51 (21.8) | 43 (23.4) | ||
| 10–12 weeks | 10 (4.3) | 62 (26.5) | 40 (21.7) | ||
| >12 weeks | 2 (0.9) | 44 (18.8) | 8 (4.3) | ||
| Neoadjuvant therapy is unavailable | 1 (0.4) | 7 (3.0) | 0 (0) | ||
Standard treatment was defined as oncological therapy offered to patients by their center prior to the SARS CoV-2 pandemic whereas in round 1 and round 2 focusses on oncological therapy used during the SARS CoV-2 pandemic. P-values in tables represent statistical testing across each variable.