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. 2020 Jun 24;40(26):5116–5136. doi: 10.1523/JNEUROSCI.0425-20.2020

Figure 7.

Figure 7.

PVBCs have selectively reduced spiking. Spiking data for PVBCs (panel subheading 1), PVBSCs (panel subheading 2), and PVAACs (panel subheading 3). A, Example LFP and cell-attached traces for CT (left) and 5xFAD (right), for a PVBC (A1), PVBSC (A2), and PVAAC (A3). Spike and SWR events are color-coded as in Figure 4B. B, Summary spike rate data for PVBCs (nPVBC = 13 CT, 16 5xFAD, B1), PVBSCs (nPVBSC = 5 CT, 10 5xFAD, B2), and PVAACs (nPVAAC = 6 CT, 6 5xFAD, B3) during spontaneous and SWR periods. C, Peri-SWR spike probability. Asterisks indicate regions surviving Šidák's multiple comparisons correction. D, Burst rate, defined as 3 or more spikes each within 40 ms. E, The fraction of SWRs with one or more spike. F, The fraction of SWRs with a burst. G-H, Polar phase plots of phase-locking of spikes to SWR-nested slow γ (G) and ripple (H). The angles of individual data points represent the average phase of all spikes for a cell. Length from origin (0–1) indicates the degree of phase-locking. Lines with arrowheads represent cell average, solid colored = CT, dashed gray = 5xFAD. Asterisks indicate result of Raleigh's test for non-uniformity, p values indicate results of Watson–Williams or circular mean test; *p < 0.05, **p < 0.01, ***p < 0.001. For all plots, individual data points represent a cell. Closed circles represent cells from males, open circles females. Box-whisker plots represent non-normal data with Median and IQRs; p values indicated above brackets.