Table 3.
Baseline blood count and biochemical markers for patients at the Modena centre only
|
Tocilizumab plus standard care group (n=125) |
Standard care group (n=179) | p value | All patients (n=304) | ||
|---|---|---|---|---|---|
| Subcutaneous (n=78) | Intravenous (n=47) | ||||
| Haemoglobin (g/dL) | 12·8 (11·5–13·7) | 13·0 (11·6–13·7) | 12·7 (11·2–14·2) | 1·0 | 12·7 (11·4–14·0) |
| White cells (mm3) | 7195 (5470–10380) | 6840 (5140–9380) | 6200 (4570–9360) | 0·22 | 6700 (4890–9560) |
| Lymphocytes (%) | 22·1 (9·7–36·8) | 18·1 (12·5–25·8) | 23·1 (9·9–39·7) | 0·60 | 20·6 (9·9–36·6) |
| Total lymphocytes (mm3) | 1580 (1390–2142) | 2459 (1852–3348) | 1390 (1000–2815) | 0·30 | 1852 (1120–2726) |
| Platelets (109/L) | 257·5 (183·0–374·0) | 211·0 (156·0–294·0) | 209·0 (155·0–298·0) | 0·0027 | 221·5 (163·0–317·0) |
| Alanine aminotransferase (U/L) | 37·0 (27·0–71·0) | 35·0 (21·5–62·5) | 31·0 (19·0–48·0) | 0·0070 | 33·0 (22·0–56·0) |
| Bilirubin (mg/dL) | 0·6 (0·4–0·7) | 0·6 (0·4–0·8) | 0·6 (0·4–0·8) | 0·74 | 0·6 (0·4–0·8) |
| Calcium (mg/dL) | 8·6 (8·4–9·1) | 8·5 (8·1–8·9) | 8·6 (8·3–9·1) | 0·26 | 8·6 (8·3–9·1) |
| Creatine kinase (U/L) | 63·0 (33·0–159·0) | 130·0 (41·5–312·0) | 71·0 (39·0–202·0) | 0·051 | 76·0 (38·0–197·5) |
| Chloride (mmol/L) | 101·0 (98·0–105·0) | 100·0 (99·0–103·0) | 101·0 (97·0–103·0) | 0·91 | 101·0 (98·0–103·0) |
| Creatinine (mg/dL) | 0·8 (0·6–0·9) | 0·9 (0·7–1·2) | 0·9 (0·7–1·1) | 0·0050 | 0·8 (0·7–1·1) |
| D-dimer (mg/mL) | 1210 (820·0–2290) | 1000 (780·0–2730) | 1240 (610·0–2480) | 0·64 | 1200 (690·0–2480) |
| Lactate dehydrogenase (U/L) | 600·0 (505·0–761·0) | 676·0 (536·0–765·0) | 507·5 (419·5–705·5) | 0·0002 | 564·0 (454·0–745·0) |
| Potassium (mmol/L) | 3·9 (3·5–4·3) | 3·8 (3·6–4·0) | 3·9 (3·5–4·3) | 0·34 | 3·9 (3·5–4·2) |
| Sodium (mmol/L) | 137·5 (136·0–139·0) | 137·0 (135·0–138·0) | 138·0 (135·0–141·0) | 0·019 | 138·0 (135·0–140·0) |
| Ferritin (mg/mL) | 1168 (543–1214) | .. | 423 (355–993) | 0·14 | 447 (355–1141) |
| C-reactive protein (mg/dL) | 3·4 (0·6–7·8) | 6·1 (1·8–15·3) | 5·4 (1·8–14·6) | 0·022 | 5·3 (1·4–13·6) |
| Interleukin-6 (pg/mL) | 190·2 (86·6–401·0) | 238·3 (140·2–731·9) | 144·1 (41·1–385·8) | 0·045 | 178·6 (67·6–402·0) |
Data are median (IQR). p values were calculated using the Kruskal-Wallis test.