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In wild-type cells, RB1 regulates entry into S-phase. However, loss of RB1 promotes an accumulation of cells in S-phase, increases apoptosis and reduces the number of photoreceptors, ganglion cells and bipolar cells. RB1 loss in retinal organoids did not result in retinoblastoma formation when injected into the vitreous body of NOD/SCID mice.
