Supplementary Table 2. Reporter metabolites.
| Metabolites | P-values | Number of edges |
|---|---|---|
| Prenyl diphosphate(3-) | 7.41E-05 | 2 |
| Isocitrate(3-) | 1.39E-04 | 1 |
| Isopentenyl diphosphate(3-) | 4.73E-04 | 3 |
| Hydrogen peroxide | 5.66E-04 | 8 |
| L-proline | 1.89E-03 | 2 |
| Cysteaminium | 2.09E-03 | 4 |
| (4-hydroxyphenyl)acetaldehyde | 2.28E-03 | 6 |
| Farnesyl pyrophosphate(3-) | 2.73E-03 | 1 |
| Geranyl diphosphate(3-) | 2.73E-03 | 1 |
| 3’-dephospho-CoA(2-) | 2.77E-03 | 6 |
| N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide | 3.57E-03 | 2 |
| N1-(5-Phospho-D-ribosyl)glycinamide | 6.95E-03 | 1 |
| L-phenylalanine | 7.01E-03 | 10 |
| GDP | 7.96E-03 | 13 |
| 3,4-Dihydroxymandelate | 8.38E-03 | 4 |
| 3,4-Dihydroxyphenylacetaldehyde | 8.38E-03 | 4 |
| (3,4-dihydroxyphenyl)acetate | 8.38E-03 | 4 |
| 3-methoxy-4-hydroxyphenylglycolaldehyde | 8.38E-03 | 4 |
| 3-Methoxy-4-hydroxymandelate | 8.38E-03 | 4 |
| 4-hydroxyphenylacetate | 8.38E-03 | 4 |
| 4-nitrophenolate | 8.38E-03 | 4 |
| 4-nitrophenyl phosphate(2-) | 8.38E-03 | 4 |
| Glycochenodeoxycholate | 8.38E-03 | 4 |
| Nicotinate D-ribonucleotide | 8.38E-03 | 4 |
| D-ribitol | 8.38E-03 | 4 |
| Core 4 | 8.63E-03 | 5 |
| (S)-2,3-epoxysqualene | 8.84E-03 | 2 |
| UDP-D-glucuronate | 9.02E-03 | 5 |
| Keratan sulfate I biosynthesis, precursor 36 | 9.49E-03 | 6 |
| Keratan sulfate II biosynthesis, precursor 10 | 9.49E-03 | 6 |
| Keratan sulfate II biosynthesis, precursor 10 | 9.49E-03 | 6 |
| L-cysteine | 9.90E-03 | 14 |
| L-cysteine | 1.03E-02 | 9 |
| Pantetheine 4’-phosphate(2-) | 1.04E-02 | 5 |
| L-leucine | 1.16E-02 | 10 |
| Cholesta-5,7-dien-3beta-ol | 1.18E-02 | 2 |
| 7-dehydrodesmosterol | 1.18E-02 | 2 |
| Uridine | 1.23E-02 | 7 |
| dCMP(2-) | 1.27E-02 | 2 |
| UDP(3-) | 1.27E-02 | 2 |
| UTP(4-) | 1.27E-02 | 2 |
| Supplementary Table 2. Continued. | ||
| Metabolites | P-values | Number of edges |
| Deamino-NAD+ | 1.30E-02 | 5 |
| Clupanodonyl CoA | 1.37E-02 | 2 |
| Gamma-linolenoyl-CoA(4-) | 1.37E-02 | 2 |
| Hydrogenphosphate | 1.58E-02 | 74 |
| {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine | 1.64E-02 | 5 |
| 3-methylimidazoleacetic acid | 1.66E-02 | 5 |
| D-ribulose 5-phosphate(2-) | 1.73E-02 | 1 |
| Diphosphate | 1.81E-02 | 10 |
| 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine | 1.83E-02 | 2 |
| Keratan sulfate I biosynthesis, precursor 11 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 14 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 17 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 20 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 23 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 26 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 29 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 32 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 35 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 5 | 1.86E-02 | 8 |
| Keratan sulfate I biosynthesis, precursor 8 | 1.86E-02 | 8 |
| Keratan sulfate II biosynthesis, precursor 6 | 1.86E-02 | 8 |
| Keratan sulfate II biosynthesis, precursor 9 | 1.86E-02 | 8 |
| Keratan sulfate II biosynthesis, precursor 6 | 1.86E-02 | 8 |
| Keratan sulfate II biosynthesis, precursor 9 | 1.86E-02 | 8 |
| UDP-D-galactose(2-) | 2.06E-02 | 9 |
| Hydrogenphosphate | 2.10E-02 | 30 |
| Ethamp[c] | 2.16E-02 | 5 |
| Acetyl-CoA | 2.19E-02 | 5 |
| (R)-Pantothenate | 2.20E-02 | 7 |
| Keratan sulfate II biosynthesis, precursor 1 | 2.42E-02 | 7 |
| Keratan sulfate II biosynthesis, precursor 1 | 2.42E-02 | 7 |
| GTP | 2.68E-02 | 12 |
| Protoheme | 2.81E-02 | 3 |
| 4,8 dimethylnonanoyl-CoA | 2.84E-02 | 1 |
| 1-pyrroline-5-carboxylate | 3.01E-02 | 3 |
| ps_hs[m] | 3.17E-02 | 3 |
| 5-phospho-beta-D-ribosylamine | 3.52E-02 | 2 |
| S-succinyldihydrolipoamide | 3.84E-02 | 2 |
| CDP(3-) | 3.99E-02 | 1 |
| CMP(2-) | 3.99E-02 | 1 |
| Supplementary Table 2. Continued. | ||
| Metabolites | P-values | Number of edges |
| dCDP(3-) | 3.99E-02 | 1 |
| dCTP | 3.99E-02 | 1 |
| dCTP | 3.99E-02 | 1 |
| dGDP(2-) | 3.99E-02 | 1 |
| dGTP | 3.99E-02 | 1 |
| dGTP | 3.99E-02 | 1 |
| GDP(3-) | 3.99E-02 | 1 |
| GTP(4-) | 3.99E-02 | 1 |
| UMP(2-) | 3.99E-02 | 1 |
| N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine | 4.03E-02 | 5 |
| dGDP | 4.26E-02 | 2 |
| Pantetheine | 4.28E-02 | 5 |
| (6R)-5,10-methenyltetrahydrofolate | 4.39E-02 | 6 |
| Hexadecenoyl-CoA (n-C16:1CoA) | 4.52E-02 | 2 |
| Vaccenyl coenzyme A | 4.52E-02 | 2 |
| Apocarboxylase (Lys residue) | 4.66E-02 | 1 |
| Apocarboxylase (Lys residue) | 4.66E-02 | 1 |
| Holocarboxylase (biotin covalent bound to Lys residue of apoC) | 4.66E-02 | 1 |
| Holocarboxylase (biotin covalent bound to Lys residue of apoC) | 4.66E-02 | 1 |
| Biotinyl-5’-AMP | 4.66E-02 | 1 |
| Biotinyl-5’-AMP | 4.66E-02 | 1 |
| Dephospho-CoA | 4.70E-02 | 5 |
| L-leucine | 4.74E-02 | 11 |
| Globoside | 4.94E-02 | 2 |
| UMP | 5.00E-02 | 1 |