Fig. 3. Distribution of tumor types as a second, third, or fourth malignancy among patients with the R337H-only and extended haplotypes.

Thirty-three probands (29 females and 4 males) developed multiple primary malignancies. Multiple primary tumors in probands with the extended haplotype (n = 30) are visualized in the upper panel. Multiple primary tumors in probands with the R337H-only haplotype (n = 3) are visualized in the lower panel.