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. 2020 Apr 7;9:e53449. doi: 10.7554/eLife.53449

Table 3. Association of burden of ultra-rare (MAF<0.0001) PTVs with healthspan and mother’s age at death is sex-specific.

Number of ultra-rare variants was calculated for each genome and tested for association with lifespan phenotypes using Cox proportional hazards model and covariates to account for population structure (see Materials and methods). Beta coefficients reported in the ’coef’ column. Bold font designates statistically significant associations. N - number of individuals analyzed, events - number of corresponding events reported in UK Biobank.

Phenotype Sex Coef Ci (2.5%) Ci (97.5%) p-value N Events
Death female 0.048 0.012 0.083 0.008 21742 450
Death male 0.041 0.011 0.070 0.007 18626 672
Mother age at death female 0.008 0.001 0.015 0.026 21320 12370
Mother age at death male 0.006 −0.002 0.013 0.130 17989 11081
Father age at death female 0.002 −0.004 0.008 0.558 20914 15679
Father age at death male −0.001 −0.008 0.006 0.796 17783 13785
Healthspan female 0.024 0.014 0.034 4.1E-06 21742 5667
Healthspan male 0.009 −0.001 0.019 0.070 18626 6037