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. 2020 May 20;6(21):eaaz8400. doi: 10.1126/sciadv.aaz8400

Fig. 1. Schematic illustration of CRET-NPs for cancer phototheranostics.

Fig. 1

CRET-NPs with a high ROS quantum yield can generate an intense PA signal by thermal expansion–induced vaporization. Because of its ROS-responsive CO2 production, the strong PA signal of CRET-NPs can be generated at the tumor tissue for a long period of time. In addition, the CRET phenomenon of NPs enhances the ROS quantum yield through both electron transfer in the oxygen-independent type I photochemical reaction and self-illumination in the oxygen-dependent type II photochemical reaction.