Skip to main content
. Author manuscript; available in PMC: 2020 Jun 24.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Aug 17;55(38):11382–11386. doi: 10.1002/anie.201603928

Scheme 1.

Scheme 1

Conditions: a) m-CPBA, CH2Cl2, 0°C; b) NaH, MeI, DMF, 000B0;C, 83% (2 steps); c) LiClO4, NaN3, CH3CN, 8000B0;C, 35%; d) tBuOK, THF, 0°C then RCH2OTf, 70–72%; e) H2, Pd/C, MeOH, room temperature, 90–91%; f) 14, tBuONa, BrettPhos, Pd(OAc)2 or Pd(dba)2, THF, 60°C, 37–43%; g) NBS, CH2Cl2, –10 °C, 94–97%; h) ArB(OH)2, K2CO3, Pd(OAc)2, cataCXium A, dioxane/H2O, microwave, 100°C, 40–49 %; i) TFA, reflux, >93%.