Table 6.
List of the KEGG pathways that should be inspected for virulence and undesirable genes.
| Map ID | Name | Gene ID | Enzyme name | Function |
|---|---|---|---|---|
| Under “Brite” Genes and Proteins; Protein families: Signaling and cellular processes | ||||
| Ko02042 | Bacterial toxins | Virulence factor | ||
| Under “Pathway” | ||||
| Carbohydrate metabolism (for D-lactate formation) | ||||
| 00620 | Pyruvate metabolism | K22373 | lactate racemase [EC:5.1.2.1] | D-lactate < -> L-lactate |
| K03778 | D-lactate dehydrogenase [EC:1.1.1.28] | Pyruvate < -> D-lactate | ||
| Lipid metabolism (for bile salt deconjugation and secondary bile acid biosynthesis) | ||||
| 00120 | Primary bile acid biosynthesis | K01442 | Choloylglycine hydrolase/bile salt hydrolase [EC:3.5.1.24] | Bile salt deconjugation |
| 00121 | Secondary bile acid biosynthesis | complete pathway | possible carcinogenic substances | |
| Amino acid metabolism (for biogenic amine formation) | ||||
| 00310 | Lysine degradation | K01582 | Lysine decarboxylase [EC:4.1.1.18] | production of cadaverine |
| K23385 | D-ornithine/D-lysine decarboxylase [EC:4.1.1.116] | production of cadaverine | ||
| 00330 | Arginine and proline metabolism | complete pathway for biogenic amine formation | ||
| K01583, K01584, K01585, K02626 | Arginine decarboxylase [EC:4.1.1.19] | arginine -> agmatine | ||
| K01480 | Agmatinase [EC:3.5.3.11] | agmatine -> putrescine | ||
| K00797 | Spermidine synthase [EC:2.5.1.16] | putrescine -> spermidine, spermine | ||
| K01476 | Arginase [EC:3.5.3.1] | arginine -> ornithine | ||
| K01581 | Ornithine decarboxylase [EC:4.1.1.17] | ornithine -> putrescine | ||
| 00340 | Histidine metabolism | K01590 | Histidine decarboxylase [EC:4.1.1.22] | histidine -> histamine |
| 00350 | Tyrosine metabolism | K22329, K22330, K01592, K18933 | Tyrosine decarboxylase [EC:4.1.1.25] | tyrosine -> tyramine |
| 00380 | Tryptophan metabolism | K01593 | Tryptophan decarboxylase [EC:4.1.1.28] | tryptophan -> tryptamine |