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. 2020 Jun 24;10:10286. doi: 10.1038/s41598-020-67175-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Adipocyte Conditioned Medium Stimulates Fibroblast Collagen Synthesis. ACM treated fibroblasts produced more than three times as much total collagen as controls and 1.5 times as much collagen as positive controls treated with TGF-β1 and ascorbic acid. A one-way ANOVA with Tukey post hoc tests indicates significant differences (*p < 0.05, **p < 0.01). Data is presented as mean ± SEM (n = 3 independent experiments with three replicates for each group).