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. 2020 Jun 24;10:10278. doi: 10.1038/s41598-020-67091-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased lysosomal area in mature PARK2 KO neurons. (A–E) Temporal changes in LAMP1 (green) immunoreactivity in iPSC-derived neurons from a healthy control and PARK2 KO cells. Cell nuclei were visualized using DAPI (blue). Scale bar: 20 µm. (F) Quantification of the area of LAMP1 + lysosomes normalized to the number of DAPI + nuclei showing no difference between PARK2 KO and control cells at days 0 and 10, and a significant increase at day 25 and later time points. Data are presented as mean ± SEM of 3 independent differentiations (n = 9). Student’s t-test, **p < 0.01, ***p < 0.001, ns: not significant.