Table 1.

Changes in lysosomal proteins identified by proteomic analysis.

Accession	Gene name	Description	PARK2 KO/Control	q-value	Unique Peptides
P27449	ATP6V0C	V-type proton ATPase 16 kDa proteolipid subunit	1.56	0.005	4
Q6IQ22	RAB12	Ras-related protein Rab-12	1.31	0.014	9
Q9Y5W7	SNX14	Sorting nexin-14	1.30	0.018	2
Q8IY95	TMEM192	Transmembrane protein 192	1.25	0.025	2
O15400	STX7	Syntaxin-7	1.23	0.036	13
Q96GC9	VMP1	Vacuole membrane protein 1	1.21	0.035	3
Q9H267	VPS33B	Vacuolar protein sorting-associated protein 33B	0.87	0.039	7
P78537	BLOC1S1	Biogenesis of lysosome-related organelles complex 1 subunit 1	0.85	0.042	3
Q969J3	BORCS5	BLOC-1 related complex subunit 5	0.85	0.037	2
Q9H305	CDIP1	Cell death-inducing p53-target protein 1	0.84	0.028	2
P07858	CTSB	Cathepsin B	0.84	0.047	2
Q9UN37	VPS4A	Vacuolar protein sorting-associated protein 4A	0.83	0.036	8
P86790	CCZ1B	Vacuolar fusion protein CCZ1 homolog B	0.82	0.020	3
Q8TAF3	WDR48	WD repeat-containing protein 48	0.81	0.042	8
O14964	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate	0.79	0.015	5
P61073	CXCR4	C-X-C chemokine receptor type 4	0.79	0.016	3
O43237	DYNC1LI2	Cytoplasmic dynein 1 light intermediate chain 2	0.74	0.017	19
Q01484	ANK2	Ankyrin-2	0.72	0.009	167
P61916	NPC2	NPC intracellular cholesterol transporter 2	0.69	0.020	3
P60520	GABARAPL2	Gamma-aminobutyric acid receptor-associated protein-like 2	0.67	0.004	6
P98164	LRP2	Low-density lipoprotein receptor-related protein 2	0.63	0.003	16
Q9H492	MAP1LC3A	Microtubule-associated proteins 1 A/1B light chain 3 A	0.57	0.003	2

Ratio of lysosomal protein levels in PARK2 KO neurons compared to that of controls; q-value (FDR-adjusted p-value) and number of unique peptides, n = 3, data based on three independent experiments.