Table 1.
Summary of the CD-GWAS results in Japanese patients.
| Chr | Range (bp)* | Top Hit SNP | No. of SNPs** | Genes | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| From | To | SNP ID | Position* | A1 | A2 | A2 Frequencies | P-Values | OR (95%CI) | |||
| 1 | 20437634 | 20437764 | rs7515774 | 20437634 | A | T | 0.107 | 1.04E-06 | 1.10 (1.06–1.15) | 2 | PLA2G2D |
| 1 | 67648596 | 67648596 | rs76418789 | 67648596 | G | A | 0.060 | 4.22E-07 | 0.88 (0.84–0.93) | 1 | IL23R (G149R) |
| 1 | 112222702 | 112222702 | rs534888 | 112222702 | C | T | 0.467 | 7.16E-06 | 0.95 (0.92–0.97) | 1 | RAP1A |
| 4 | 38324507 | 38373273 | rs55843528 | 38361416 | G | A | 0.245 | 1.89E-07 | 1.08 (1.05–1.11) | 20 | — |
| 4 | 189893313 | 189893313 | rs12647478 | 189893313 | T | C | 0.391 | 7.58E-06 | 0.92 (0.88–0.95) | 1 | — |
| 5 | 67691469 | 67691469 | rs10068082 | 67691469 | G | A | 0.037 | 1.72E-06 | 1.17 (1.10–1.26) | 1 | PIK3R1 |
| 5 | 158826792 | 158853941 | rs56167332 | 158827769 | C | A | 0.402 | 3.11E-07 | 1.07 (1.04–1.09) | 21 | IL12B |
| 6 | 2957827 | 2966578 | rs79536569 | 2957827 | G | A | 0.017 | 3.50E-06 | 1.23 (1.13–1.35) | 2 | SERPINB6 |
| 6 | 32214010 | 32793981 | rs184950714 | 32636728 | G | A | 0.179 | 1.07E-17 | 1.16 (1.12–1.19) | 452 | (HLA) |
| 7 | 12221801 | 12222116 | rs200319458 | 12221801 | T | C | 0.024 | 8.41E-06 | 1.19 (1.10–1.29) | 2 | TMEM106B |
| 7 | 76948351 | 76948351 | rs4727354 | 76948351 | G | T | 0.051 | 3.31E-06 | 1.14 (1.08–1.20) | 1 | GSAP |
| 8 | 70472493 | 70472493 | rs117742432 | 70472493 | G | A | 0.036 | 6.58E-06 | 0.86 (0.81–0.92) | 1 | SULF1 |
| 8 | 129224694 | 129245849 | rs12678162 | 129224694 | T | C | 0.431 | 3.08E-06 | 1.06 (1.03–1.08) | 4 | PVT1 |
| 9 | 73881874 | 73881874 | rs151258497 | 73881874 | — | C | 0.331 | 4.57E-06 | 0.94 (0.92–0.97) | 1 | TRPM3 |
| 9 | 117480416 | 117697947 | rs55951892 | 117575913 | A | C | 0.490 | 1.76E-23 | 0.89 (0.86–0.91) | 129 | TNFSF15 |
| 10 | 64431973 | 64550071 | rs224136 | 64470675 | C | T | 0.275 | 1.18E-07 | 0.93 (0.90–0.95) | 19 | ZNF365 |
| 11 | 64908062 | 64926722 | rs11227126 | 64908062 | A | T | 0.067 | 1.71E-06 | 1.12 (1.07–1.18) | 3 | SYVN1 |
| 14 | 105695957 | 105695957 | rs117952084 | 105695957 | T | C | 0.021 | 9.73E-06 | 0.83 (0.76–0.90) | 1 | BRF1 |
| 15 | 27156539 | 27156539 | rs781387485 | 27156539 | ACACAA | — | 0.095 | 3.36E-06 | 1.11 (1.06–1.16) | 1 | GABRA5 |
| 16 | 28513068 | 28531287 | rs56354901 | 28523144 | T | C | 0.134 | 2.44E-06 | 1.09 (1.05–1.13) | 3 | NPIPL1, IL27 |
| 19 | 30021446 | 30021446 | rs117223925 | 30021446 | G | A | 0.075 | 6.21E-06 | 0.90 (0.86–0.94) | 1 | VSTM2B |
| 20 | 47804952 | 47804952 | NA | 47804952 | — | CCCGGC | 0.020 | 2.57E-06 | 1.21 (1.12–1.32) | 1 | STAU1 |
| 20 | 51548302 | 51548302 | rs6126698 | 51548302 | A | T | 0.484 | 8.31E-06 | 0.94 (0.91–0.97) | 1 | TSHZ2 |
| 21 | 33326781 | 33326781 | rs2833577 | 33326781 | G | A | 0.286 | 1.23E-06 | 1.07 (1.04–1.11) | 1 | HUNK |
| 22 | 23054614 | 23054614 | rs9623882 | 23054614 | G | A | 0.081 | 1.61E-06 | 1.14 (1.08–1.20) | 1 | GGTLC2 |
*Positions are based on the Genome Reference Consortium human build 37 (GRCh37), **Number of SNPs with p values <1 × 10−5 Chr: Chromosome, OR: Odds ratio, CI: Confidential interval.