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. 2020 Jun 24;10:10288. doi: 10.1038/s41598-020-67215-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional properties of wild-type and mutant channels. (A) I-V relationships of whole-cell currents from transiently transfected cells. Current amplitudes were normalised to cell capacitance and plotted against test potentials. Solid lines are connectors of experimental data. (B) voltage dependence of current activation. The voltage dependence of channel activation was estimated from G-V relationships. Individual G-V relationships were normalized with respect to corresponding maximal conductance of each cell. (C) voltage dependence of steady-state fast current inactivation. Currents were normalised with respect to the maximal current amplitude of each cell. (D) voltage dependence of current inactivation evoked by prolonged 1 s conditioning prepulse normalised in respect to the maximal current amplitude of each cell. (E) recovery from steady-state fast inactivation. Solid lines are mean fits of single exponential relationships of the data. Solid lines in panels B,C,D represent fits of experimental data by Boltzmann relationships. Individual symbols are explained in panel A.