Table 3.

Univariate and multivariate analysis for relapse-free survival of rectal cancer was performed in each clinical stage.

Stage	I				IIa				IIb				IIc		IIIa				IIIb				IIIc
Factors	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis
	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P
Age
75≥/<75	1.66	0.048	1.52	0.10	1.16	0.43	—	—	0.92	0.83			0.86	0.77	2.36	0.028	1.74	0.16	1.09	0.55	—	—	0.95	0.85
Gender
M/F	0.84	0.38	—	—	1.27	0.12	—	—	0.90	0.71			1.37	0.35	1.79	0.07			1.27	0.03	1.24	0.054	1.15	0.39
Histology
Diff/Undiff	1.04	0.96	—	—	0.97	0.94	—	—	0.51	0.19	0.45	0.14	0.43	0.12	0.31	0.056			1.06	0.83	—	—	0.64	0.049
Dissected LN
12 > /12≤	1.38	0.13	—	—	1.11	0.55	—	—	1.54	0.2.			1.86	0.24	0.98	0.95			1.60	0.0007	1.54	0.007	0.85	0.90
Adjuvant
Yes/No	1.99	0.089	—	—	1.46	0.029	1.36	0.07	1.27	0.44			1.00	1.00	0.42	0.006	0.53	0.053	0.75	0.014	0.76	0.02	0.90	0.56
TM-LVI
C/A	3.40	<0.0001	3.24	0.0002	2.66	<0.0001	2.59	<0.0001	2.98	0.0004	3.25	0.0003	1.22	0.50	5.61	0.0005	4.15	0.002	2.13	<0.0001	2.07	<0.0001	1.30	0.06
B/A	2.29		2.24		1.80		1.77		0.88		0.98		0.74		2.33		2.42		1.37		1.32		0.84
C/B	1.49		1.45		1.48		1.47		3.38		3.30		1.65		2.41		1.71		1.56		1.56		1.54

TM-LVI was an independent prognostic factor for relapse-free survival of rectal cancer in stage I, IIa, IIb, IIIa, and IIIb.

M/F, Male/Female; Diff/Undiff, Differentiated/Undifferentiated; LN, Lymph node; RR, Risk ratio; Bold type, P < 0.05.