Table 4.

Univariate and multivariate analysis for disease specific survival of colon cancer was performed in each clinical stage.

Stage	I		IIa				IIb				IIc		IIIa		IIIb				IIIc
Factors	Univariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Univariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P	RR	P
Age
75≥/<75	1.15	0.83	2.21	0.0006	2.01	0.0025	1.97	0.051	1.78	0.10	1.79	0.2	1.49	0.64	1.35	0.052			1.30	0.20
Gender
M/F	1.58	0.44	1.39	0.14			0.80	0.49			1.00	1.0	0.88	0.85	1.42	0.01	1.41	0.02	1.10	0.57
Histology
Diff/Undiff	6.8×108	0.44	5.23	0.026	4.67	0.04	2.00	0.29			1.45	0.6	1.9×109	0.37	0.75	0.26			0.61	0.02	0.63	0.03
Dissected LN
12 > /12≤	0.65	0.64	2.64	0.0002	2.21	0.004	1.41	0.64			1.26	0.68	ND	0.88	1.49	0.049	1.41	0.1	1.54	0.15
Adjuvant
Yes/No	1.5×10−8	0.43	0.62	0.19			1.47	0.28			0.33	0.09	0.86	0.84	0.90	0.46			0.92	0.64
TM-LVI
C/A	1.6×10−9	0.13	2.85	0.0003	2.80	0.0009	3.68	0.003	3.47	0.006	2.29	0.3	4.61	0.14	2.64	<0.0001	2.64	<0.0001	2.65	<0.0001	2.63	<0.0001
B/A	1.6×10−9		2.25		2.04		1.53		1.51		1.38		4.05		1.68		1.67		1.53		1.53
C/B	1.0		1.27		1.37		2.41		2.30		1.66		1.14		1.57		1.58		1.73		1.72

TM-LVI was an independent prognostic factor for relapse-free survival of colon cancer in stage IIa, IIb, IIIb, and IIIc.

M/F, Male/Female; Diff/Undiff, Differentiated/Undifferentiated; LN, Lymph node; RR, Risk ratio; Bold type, P < 0.05.