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. 2020 Jun 24;7:198. doi: 10.1038/s41597-020-0545-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic overview of the experimental and data analysis design. (a) A total of 50 patients were included in this study and standardized serum samples were obtained from the pulmonary artery (PA) and left atrium (LA) before cardiopulmonary bypass (Pre-CPB), at the end of CPB (Post-CPB), and at 2, 4, 8, and 20 hours postoperatively. (b) Samples were run on a 600 MHz nuclear magnetic resonance (NMR) spectroscopy apparat. (c) Processed data have been deposited at the MetaboLights database (http://www.ebi.ac.uk/metabolights) of the European Bioinformatics Institute under MTBLS88¹². (d) NMR spectral data and metabolite quantification were checked by different approaches to ensure data quality. (e) Multivariate and univariate data analysis was performed to identify metabolite changes as a consequence of ischemia-reperfusion. Parts of the figure have been reprinted with permission^8,9.