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. 2020 Jun 24;10:10283. doi: 10.1038/s41598-020-67288-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FOLR3 secretes into cell supernatant and reduces homocysteine induced-neurotoxicity. (A) The FOLR3 expression in the empty vector or FOLR3+ cells culture supernatant. (B) The effect of supetnatant of FOLR3-overexpressed HEK293 cell on homocysteine-induced toxicity in SH-SY%Y. Two-way ANOVA with SIdak’s test for multiple comparisons was used for statistical analysis and all data presented mean ± S.E. (n = 3) *p < 0.05, ***p < 0.001 n.s.; not signicant.