Table 3.
Estimated values obtained from the Cosinor model of fold changes in the expression of genes encoding estrogen receptors and progesterone receptor in mammary glands from pubertal mice fed AIN93G or high-fat diet.
| mRNA | Amplitude | p | ||
|---|---|---|---|---|
| AIN93Ga | High-Fata | Difference (95% CI)b | ||
| Esr1 | 0.66 ± 0.08 | 0.79 ± 0.08 | 0.13 (−0.10 to 0.35) | 0.28 |
| Esr2 | 2.38 ± 0.17 | 1.56 ± 0.17 | −0.82 (−1.29 to −0.36) | <0.01 |
| Pgr | 0.58 ± 0.10 | 0.71 ± 0.09 | 0.13 (−0.13 to 0.39) | 0.33 |
| mRNA | Acrophase (Hours) | p | ||
| AIN93Ga | High-Fata | Difference (95% CI)b | ||
| Esr1 | 6.93 ± 0.42 | 5.96 ± 0.35 | −0.97 (−2.05 to 0.11) | 0.08 |
| Esr2 | 6.96 ± 0.24 | 6.27 ± 0.36 | −0.70 (−1.55 to 0.16) | 0.11 |
| Pgr | 6.90 ± 0.56 | 9.69 ± 0.50 | 2.79 (1.31 to 4.28) | <0.01 |
| mRNA | Midline estimating statistic of rhythm (mesor) | p | ||
| AIN93Ga | High-Fata | Difference (95% CI)b | ||
| Esr1 | 1.04 ± 0.05 | 1.15 ± 0.05 | 0.12 (−0.04 to 0.27) | 0.13 |
| Esr2 | 1.97 ± 0.11 | 1.50 ± 0.11 | −0.47 (−0.79 to −0.16) | <0.01 |
| Pgr | 0.90 ± 0.06 | 1.44 ± 0.06 | 0.54 (0.36 to 0.72) | <0.01 |
a
estimates ± standard error (SE) for the AIN93G and the high-fat diet groups.
b
estimated difference and its 95% confidence interval (95% CI) between the AIN93G and the high-fat diet groups.