Table 4.
Estimated values from the Cosinor model of concentrations of estrogen, progesterone, and their receptors in mammary glands from pubertal mice fed AIN93G or high-fat diet.
| Amplitude | ||||
|---|---|---|---|---|
| AIN93Ga | High-Fata | Difference (95% CI)b | p | |
| Estrogen, pg/mg | 3.84 ± 1.06 | 2.01 ± 1.04 | −1.83 (−4.78 to 1.12) | 0.22 |
| Esr1, μg/mg | 0.11 ± 0.08 | 0.34 ± 0.09 | 0.23 (−0.02 to 0.47) | 0.07 |
| Esr2, ng/mg | 15.77 ± 3.29 | 12.88 ± 3.32 | −2.89 (−12.13 to 6.36) | 0.54 |
| Progesterone, ng/mg | 0.23 ± 0.06 | 0.07 ± 0.06 | −0.16 (−0.33 to 0.02) | 0.08 |
| Pgr, ng/mg | 0.91 ± 0.25 | 0.98 ± 0.26 | 0.07 (−0.65 to 0.79) | 0.85 |
| Acrophase (Hours) | ||||
| AIN93Ga | High-Fata | Difference (95% CI)b | p | |
| Estrogen | 16.63 ± 0.99 | 17.94 ± 1.76 | 1.32 (−2.68 to 5.31) | 0.52 |
| Esr1 | 21.63 ± 3.16 | 16.53 ± 0.95 | −5.10 (−11.62 to 1.42) | 0.12 |
| Esr2 | 16.42 ± 0.73 | 17.30 ± 0.90 | 0.87 (−1.43 to 3.17) | 0.46 |
| Progesterone | 16.26 ± 0.97 | 16.68 ± 3.06 | 0.43 (−5.93 to 6.78) | 0.89 |
| Pgr | 21.00 ± 1.06 | 17.63 ± 0.92 | −3.37 (−6.15 to −0.58) | <0.05 |
| Midline estimating statistic of rhythm (mesor) | ||||
| AIN93Ga | High-Fata | Difference (95% CI)b | p | |
| Estrogen, pg/mg | 4.77 ± 0.73 | 8.43 ± 0.70 | 3.67 (1.67 to 5.66) | <0.01 |
| Esr1, μg/mg | 0.90 ± 0.06 | 1.21 ± 0.06 | 0.30 (0.13 to 0.47) | <0.01 |
| Esr2, ng/mg | 60.60 ± 2.23 | 42.19 ± 2.26 | −18.40 (−24.68 to 12.12) | <0.01 |
| Progesterone, ng/mg | 0.36 ± 0.04 | 0.40 ± 0.04 | 0.05 (−0.07 to 0.16) | 0.45 |
| Pgr, ng/mg | 3.17 ± 0.18 | 3.85 ± 0.18 | 0.68 (0.19 to 1.18) | <0.01 |
a
estimates ± standard error (SE) for the AIN93G and the high-fat diet groups.
b
estimated difference and its 95% confidence interval (95% CI) between the AIN93G and the high-fat diet groups.