TABLE 3.

Positive detection rates of ColoDefense test with different algorithm combinations for mSEPT9 and mSDC2 in detecting AA, CRC, and control.

Algorithm		Group	Subject number (n)	Positive detection rate (95% CI:%)	Youden index (%)
mSEPT9	mSDC2
3/3	2/3	AA	6	83.3 (36.5–99.1)	54.1
		CRC	55	94.5 (83.9–98.6)	65.3
		Control	65	29.2 (18.9–42.0)	N/A
3/3	3/3	AA	6	66.7 (24.1–94.0)	42.1
		CRC	55	90.9 (3.4–20.7)	66.3
		Control	65	24.6 (15.1–37.1)	N/A
3/3 and mean Ct <40	2/3	AA	6	83.3 (36.5–99.1)	60.3
		CRC	55	90.9 (3.4–20.7)	67.8
		Control	65	23.1 (13.9–35.5)	N/A
3/3 and mean Ct <40	3/3	AA	6	66.7 (24.1–94.0)	48.2
		CRC	55	87.3 (74.9–94.3)	68.8
		Control	65	18.5 (10.3–30.4)	N/A
3/3 and mean Ct <39	2/3	AA	6	83.3 (36.5–99.1)	71.0
		CRC	55	89.1 (77.1–95.5)	76.8
		Control	65	12.3 (5.8–23.4)	N/A
3/3 and mean Ct <39	3/3	AA	6	66.7 (24.1–94.0)	59.0
		CRC	55	87.3 (74.9–94.3)	79.6
		Control	65	7.7 (2.9–17.8)	N/A
3/3 and mean Ct <38	2/3	AA	6	66.7 (24.1–94.0)	57.4
		CRC	55	89.1 (77.1–95.5)	79.9
		Control	65	9.2 (3.8–19.7)	N/A
3/3 and mean Ct <38	3/3	AA	6	50.0 (13.9–86.1)	43.8
		CRC	55	87.3 (74.9–94.3)	81.1
		Control	65	6.2 (2.0–15.8)	N/A

N/A, not applicable.