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. 2020 Jun 18;10:982. doi: 10.3389/fonc.2020.00982

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Copyright © 2020 Xie, Li, Li, Li, Zhang, Binang, Zhao, Duan, Chen, Wang, Du and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between the circ-PNN and CRC. (A) The relative expression of serum exosomal circ-PNN (relative to β-actin) in patients with CRC (n = 88) and healthy controls (n = 88) determined using RT-qPCR assay in the training set, ***P < 0.001. (B) ROC curve analysis for the determination of the diagnostic performance of circ-PNN in the training set. (C) The relative expression of serum exosomal circ-PNN (relative to β-actin) in patients with CRC (n = 58) and control individuals (n = 58) determined using RT-qPCR assay in the validation set, ***P < 0.001. (D) ROC curves for the determination of the diagnostic performance of circ-PNN in the validation set. (E) ROC curve showing the capability of serum exosomal circ-PNN in distinguishing patients with early-stage CRC from normal healthy individuals. (F) ROC curve showing the capability of serum exosomal circ-PNN in distinguishing patients with Lymph node metastasis.