Table 1.
Univariate and Multivariate analysis of prognostic factors for CRLM patients.
| Variable | Univariate analyses | Multivariate analyses | ||
|---|---|---|---|---|
| HR (95%CI) | Pb | HR (95%CI) | Pb | |
| Age | ||||
| ≤ 60 yrs | 1 | 1 | ||
| >60 yrs | 1.42(1.33-1.52) | 0.000 | 1.41(1.33-1.52) | 0.000 |
| Gender | ||||
| Female | 1 | − | − | |
| Male | 1.01(0.94-1.08) | 0.799 | − | − |
| Race | ||||
| White | 1 | 1 | ||
| Black | 1.27(1.17-1.40) | 0.000 | 1.26(1.16-1.38) | 0.000 |
| Other | 0.89(0.79-0.99) | 0.043 | 0.91(0.81-1.02) | 0.108 |
| Marriage | ||||
| Married | 1 | 1 | ||
| Divorced | 1.33(1.22-1.45) | 0.000 | 1.24(1.14-1.35) | 0.000 |
| Single | 1.27(1.17-1.39) | 0.000 | 1.30(1.19-1.41) | 0.000 |
| Unknown | 1.16(0.99-1.40) | 0.062 | 1.08(0.92-1.27) | 0.320 |
| Location | ||||
| Colon | 1 | 1 | ||
| Rectum | 0.84(0.77-0.92) | 0.000 | 0.94(0.85-1.03) | 0.160 |
| Histology | ||||
| Adenocarcinoma | 1 | 1 | ||
| Mucinous adenocarcinoma | 1.30(1.13-1.49) | 0.000 | 1.23(1.07-1.40) | 0.003 |
| Signet ring cell carcinoma | 1.27(0.68-2.37) | 0.445 | 0.89(0.48-1.67) | 0.724 |
| Differential grade | ||||
| Well | 1 | 1 | ||
| Moderate | 0.88(0.75-1.04) | 0.137 | 0.91(0.77-1.07) | 0.234 |
| Poor/Undifferentiated | 1.42(1.20-1.68) | 0.000 | 1.37(1.15-1.62) | 0.00 |
| T-classificationa | ||||
| T1 | 1 | 1 | ||
| T2 | 0.35(0.27-0.45) | 0.000 | 0.36(0.28-0.46) | 0.000 |
| T3 | 0.51(0.45-0.57) | 0.000 | 0.45(0.39-0.51) | 0.000 |
| T4 | 0.76(0.67-0.86) | 0.870 | 0.64(0.55-0.73) | 0.000 |
| N-classificationa | ||||
| N0 | 1 | 1 | ||
| N1 | 0.96(0.87-1.05) | 0.337 | 1.04(0.95-1.14) | 0.402 |
| N2 | 1.25(1.14-1.36) | 0.000 | 1.32(1.20-1.45) | 0.000 |
| CEAc | ||||
| Negative | 1 | 1 | ||
| Positive | 1.72(1.54-1.92) | 0.000 | 1.64(1.47-1.82) | 0.000 |
| Unknown | 1.73(1.53-1.94) | 0.000 | 1.66(1.47-1.87) | 0.000 |
CRLM, metastatic liver colorectal cancer; CEA, carcinoembryonic antigen.
a
T classification was classified as T1, T2, T3, T4 subgroups and N classification was classified as N0, N1, N2 according to the 7th AJCC TNM staging system.
b
Univariate and multivariate analyses were conducted using Cox proportional hazards regression model.
c
The reference value of CEA : nonsmoker <2.5ng/ml; smoker <5ng/ml.