Table 3.
Multivariate analysis of CRLM patients with T1/2 classification.
| Variable | Multivariate analyses | |
|---|---|---|
| HR (95%CI) | Pb | |
| Age | ||
| ≤ 60 yrs | 1 | |
| >60 yrs | 1.38(1.12-1.70) | 0.002 |
| Gender | ||
| Female | 1 | |
| Male | 0.93(0.75-1.15) | 0.501 |
| Race | ||
| White | 1 | |
| Black | 1.29(0.98-1.70) | 0.061 |
| Other | 1.04(0.75-1.45) | 0.810 |
| Marriage | ||
| Married | 1 | |
| Divorced | 1.26(0.96-1.65) | 0.099 |
| Single | 1.46(1.13-1.90) | 0.004 |
| Unknown | 0.99(0.63-1.54) | 0.951 |
| Location | ||
| Colon | 1 | |
| Rectum | 0.99(0.79-1.25) | 0.968 |
| Histology | ||
| Adenocarcinoma | 1 | |
| Mucinous adenocarcinoma | 1.46(0.79-2.71) | 0.226 |
| Signet ring cell carcinoma | 3.63(0.89-14.80) | 0.073 |
| Differential grade | ||
| Well | 1 | |
| Moderate | 0.88(0.59-1.30) | 0.511 |
| Poor/Undifferentiated | 1.61(1.03-2.52) | 0.038 |
| N-classificationa | ||
| N0 | 1 | |
| N1 | 0.72(0.62-0.91) | 0.005 |
| N2 | 0.49(0.30-0.79) | 0.004 |
| CEAc | ||
| Negative | 1 | |
| Positive | 2.28(1.47-3.54) | 0.000 |
| Unknown | 2.09(1.31-3.34) | 0.002 |
CRLM, metastatic liver colorectal cancer; CEA, carcinoembryonic antigen.
a
N classification was classified as N0, N1, N2 according to the 7th AJCC TNM staging system.
b
P values was conducted using Cox proportional hazards regression model.
c
The reference value of CEA : nonsmoker <2.5ng/ml; smoker <5ng/ml.