FIGURE 1.

Fractalkine levels are decreased in the striatum of R6/1 mice. Histograms show the mHtt-induced fold change of CX3CR1 (A) and FKN (B) expression quantified by qRT-PCR in the striatum of R6/1 male mice relative to WT littermates (1-week WT n = 3, 8-week WT n = 5, 12-week WT n = 8, 20-week WT n = 6, 30-week WT n = 4; 1-week R6/1 n = 7, 8-week R6/1 n = 5, 12-week R6/1 n = 10, 20-week R6/1 n = 6, 30-week R6/1 n = 4) (C) Quantification (left) and representative immunoblots of striatal lysates (right) of FKN levels at different ages of R6/1 mice and their corresponding WT littermates. β-actin was used as loading control. Data are expressed as a percentage of WT mice. (n = 3 mice/group, except the 8-week R6/1 group with n = 5). Two-tailed unpaired t-test; *p < 0.05; **p < 0.01.