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Spontaneous Germinal Center reaction. Flow cytometric analysis of germinal center (GC) B220+ B cells (A) and CD4+ T follicular helper (TFH) cells (B) in the spleen of WT NOD and B1411-IgμhomIgκhom mice in the absence of any stimulation (left). Scatter dot plot showing frequencies of TFH and GC B cells in WT NOD (black circles) and B1411-IguhomIgkhom (blue triangle). ***indicates p-value < 0.001. ** indicates p-value < 0.01. Error bars are expressed as mean ± SEM.
