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. 2020 Jun 18;11:539. doi: 10.3389/fphys.2020.00539

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Copyright © 2020 Yu, Li, Zhao, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JMJD1C represses AMPK activation in cardiomyocytes. (A,B) The AMPK signaling pathway is repressed in hypertrophic hearts in humans and mice. **p < 0.01 vs. control or saline. n = 4 in each group. (C) Jmjd1c knockdown activates AMPK signaling. NRCMs were infected with adenovirus expressing shJmjd1c or shCtrl for 24 h, followed by Ang II treatment for an additional 24 h. **p < 0.01 vs. Ad-shCtrl. n = 3 in each group. (D) JMJD1C overexpression represses AMPK activation. NRCMs were infected with adenovirus expressing Jmjd1c for 24 h, followed by Ang II treatment for an additional 24 h. **p < 0.01 vs. Ad-Ctrl. n = 3 in each group.