Fig. 3.

(a) Adapted from (Saez et al. 2014). Neurons contain glycogen, which is mobilized in hypoxia. Glycogen content was determined in control (Normoxia, exposed to environmental 21% O2) and treated neurons (Hypoxia, exposed to 1% O2) and represents the mean ± s.e.m. (n.7). ∗∗∗P < 0.001 versus Normoxia. (b) Adapted from (Saez et al. 2014). Glycogen synthase (GS) has a protective role in neurons under hypoxia. Death fold change after increasing exposure to hypoxia in GS wild-type (WT) (black) and knockout (KO) (white) neurons. (c) Adapted from (Duran et al. 2019). Performance of control and GYS1^Camk2a-KO mice was studied in an operant conditioning task. Mice were placed in a Skinner box and trained to press a lever to obtain a pellet only when a light bulb was switched on. Control mice outperformed GYS1^Camk2a-KO mice [F(9,225) = 2.82; P = 0.01]