TABLE 6.
Qualitative BioFire PN panel performance for bacteria using qRefCx and SOC as comparators
| Organism | Specimena | qRefCx (103.5 cutoff) |
SOCb |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Sensitivity |
Specificity |
Sensitivity |
Specificity |
||||||
| TP/(TP+FN) | % (95% CI) | TN/(TN+FP) | % (95% CI) | TP/(TP+FN) | % (95% CI) | TN/(TN+FP) | % (95% CI) | ||
| A. calcoaceticus-A. baumannii complex | BAL | 0/0 | 839/846 | 99.2 (98.3–99.6) | 2/2 | 100 (34.2–100) | 831/836 | 99.4 (98.6–99.7) | |
| SPU | 10/11 | 90.9 (62.3–98.4) | 807/825 | 97.8 (96.6–98.6) | 12/15 | 80.0 (54.8–93.0) | 789/805 | 98.0 (96.8–98.8) | |
| E. cloacae complex | BAL | 11/12 | 91.7 (64.6–98.5) | 822/834 | 98.6 (97.5–99.2) | 15/17 | 88.2 (65.7–96.7) | 813/821 | 99.0 (98.1–99.5) |
| SPU | 11/12 | 91.7 (64.6–98.5) | 803/824 | 97.5 (96.1–98.3) | 12/13 | 92.3 (66.7–98.6) | 788/807 | 97.6 (96.4–98.5) | |
| E. coli | BAL | 12/12 | 100 (75.8–100) | 826/834 | 99.0 (98.1–99.5) | 16/17 | 94.1 (73.0–99.0) | 817/821 | 99.5 (98.8–99.8) |
| SPU | 23/24 | 95.8 (79.8–99.3) | 787/812 | 96.9 (95.5–97.9) | 20/22 | 90.9 (72.2–97.5) | 771/798 | 96.6 (95.1–97.7) | |
| H. influenzae | BAL | 10/10 | 100 (72.2–100) | 764/836 | 91.4 (89.3–93.1) | 25/25 | 100 (86.7–100) | 757/813 | 93.1 (91.2–94.7) |
| SPU | 16/18 | 88.9 (67.2–96.9) | 727/818 | 88.9 (86.5–90.9) | 30/32 | 93.8 (79.9–98.3) | 715/788 | 90.7 (88.5–92.6) | |
| K. aerogenes | BAL | 6/7 | 85.7 (48.7–97.4) | 832/839 | 99.2 (98.3–99.6) | 8/11 | 72.7 (43.4–90.3) | 823/827 | 99.5 (98.8–99.8) |
| SPU | 3/4 | 75.0 (30.1–95.4) | 823/832 | 98.9 (98.0–99.4) | 6/7 | 85.7 (48.7–97.4) | 807/813 | 99.3 (98.4–99.7) | |
| K. oxytoca | BAL | 2/2 | 100 (34.2–100) | 835/844 | 98.9 (98.0–99.4) | 4/7 | 57.1 (25.0–84.2) | 824/831 | 99.2 (98.3–99.6) |
| SPU | 9/9 | 100 (70.1–100) | 817/827 | 98.8 (97.8–99.3) | 7/8 | 87.5 (52.9–97.8) | 801/812 | 98.6 (97.6–99.2) | |
| K. pneumoniae group | BAL | 15/15 | 100 (79.6–100) | 819/831 | 98.6 (97.5–99.2) | 18/19 | 94.7 (75.4–99.1) | 810/819 | 98.9 (97.9–99.4) |
| SPU | 21/23 | 91.3 (73.2–97.6) | 769/813 | 94.6 (92.8–95.9) | 31/33 | 93.9 (80.4–98.3) | 754/787 | 95.8 (94.2–97.0) | |
| M. catarrhalis | BAL | 0/0 | – | 817/846 | 96.6 (95.1–97.6) | 9/9 | 100 (70.1–100) | 810/829 | 97.7 (96.4–98.5) |
| SPU | 5/5 | 100 (56.6–100) | 761/831 | 91.6 (89.5–93.3) | 23/24 | 95.8 (79.8–99.3) | 746/796 | 93.7 (91.8–95.2) | |
| Proteus spp. | BAL | 5/5 | 100 (56.6–100) | 837/841 | 99.5 (98.8–99.8) | 5/5 | 100 (56.6–100) | 829/833 | 99.5 (98.8–99.8) |
| SPU | 15/15 | 100 (79.6–100) | 813/821 | 99.0 (98.1–99.5) | 6/7 | 85.7 (48.7–97.4) | 797/813 | 98.0 (96.8–98.8) | |
| P. aeruginosa | BAL | 36/36 | 100 (90.4–100) | 772/810 | 95.3 (93.6–96.6) | 49/53 | 92.5 (82.1–97.0) | 762/785 | 97.1 (95.6–98.0) |
| SPU | 103/106 | 97.2 (92.0–99.0) | 673/730 | 92.2 (90.0–93.9) | 115/122 | 94.3 (88.6–97.2) | 654/698 | 93.7 (91.6–95.3) | |
| S. marcescens | BAL | 6/6 | 100 (61.0–100) | 834/840 | 99.3 (98.5–99.7) | 8/8 | 100 (67.6–100) | 826/830 | 99.5 (98.8–99.8) |
| SPU | 26/27 | 96.3 (81.7–99.3) | 782/809 | 96.7 (95.2–97.7) | 25/29 | 86.2 (69.4–94.5) | 763/791 | 96.5 (94.9–97.5) | |
| S. aureus | BAL | 46/47 | 97.9 (88.9–99.6) | 729/799 | 91.2 (89.1–93.0) | 69/75 | 92.0 (83.6–96.3) | 717/763 | 94.0 (92.1–95.4) |
| SPU | 111/112 | 99.1 (95.1–99.8) | 631/724 | 87.2 (84.5–89.4) | 124/133 | 93.2 (87.6–96.4) | 612/687 | 89.1 (86.5–91.2) | |
| S. agalactiae | BAL | 1/1 | – | 821/845 | 97.2 (95.8–98.1) | 5/5 | 100 (56.6–100) | 813/833 | 97.6 (96.3–98.4) |
| SPU | 9/9 | 100 (70.1–100) | 793/827 | 95.9 (94.3–97.0) | 10/10 | 100 (72.2–100) | 778/810 | 96.0 (94.5–97.2) | |
| S. pneumoniae | BAL | 5/5 | 100 (56.6–100) | 817/841 | 97.1 (95.8–98.1) | 12/13 | 92.3 (66.7–98.6) | 808/825 | 97.9 (96.7–98.7) |
| SPU | 16/16 | 100 (80.6–100) | 785/820 | 95.7 (94.1–96.9) | 10/13 | 76.9 (49.7–91.8) | 768/807 | 95.2 (93.5–96.4) | |
| S. pyogenes | BAL | 2/2 | 100 (34.2–100) | 838/844 | 99.3 (98.5–99.7) | 5/5 | 100 (56.6–100) | 831/833 | 99.8 (99.1–99.9) |
| SPU | 6/6 | 100 (61.0–100) | 825/830 | 99.4 (98.6–997) | 5/6 | 83.3 (43.6–97.0) | 808/814 | 99.3 (98.4–99.7) | |
a
SPU, sputum.
b
Any result in subject medical record.