TABLE 9.
Performance of the BioFire PN panel for AMR determinants compared to independent PCR/sequencing
| Analytea | Specimen | Positive percent agreement |
Negative percent agreement |
||
|---|---|---|---|---|---|
| TP/(TP+FN) | % (95% CI) | TN/(TN+FP) | % (95% IC) | ||
| mecA/mecC + MREJ | BAL | 40/45 | 88.9 (76.5–95.2) | 64/70 | 91.4 (82.5–96.0) |
| SPU | 94/98 | 95.9 (90.0–98.4) | 91/104 | 87.5 (79.8–92.5) | |
| KPC | BAL | 2/2 | 100 (34.2–100) | 148/149 | 99.3 (96.3–99.9) |
| SPU | 7/7 | 100 (64.6–100) | 284/284 | 100 (98.7–100) | |
| NDM | BAL | 0/1 | 0 | 149/150 | 99.3 (96.3–99.9) |
| SPU | 0/0 | 291/291 | 100 (98.7–100) | ||
| OXA-48 | BAL | 0/0 | 151/151 | 100 (97.5–100) | |
| SPU | 0/0 | 291/291 | 100 (98.7–100) | ||
| VIM | BAL | 0/0 | 151/151 | 100 (97.5–100) | |
| SPU | 1/1 | 100 (20.7–100) | 289/290 | 99.7 (98.1–99.9) | |
| IMP | BAL | 0/0 | 151/151 | 100 (97.5–100) | |
| SPU | 0/0 | 291/291 | 100 (98.7–100) | ||
| CTX-M | BAL | 6/7 | 85.7 (48.7–97.4) | 144/144 | 100 (97.4–100) |
| SPU | 8/10 | 80 (49.0–94.3) | 280/281 | 99.6 (98.0–99.9) | |
a
Reported only when an applicable host organism is also detected by the BioFire PN panel (see Table 1, footnotes b, c, and d).