TABLE 2.

BFPP performance summary for BAL-type and sputum-type specimens

Analytec	PPA			NPA			BFPP-pos SOC-NTb	BFPP-neg SOC-NT
	Prop.a	%	95% CId (%)	Prop.	%	95% CId (%)
Viruses
Rhinovirus/enterovirus	5/5	100	56.6–100	103/103	100	96.4–100	4	88
Influenza A virus	4/5	80	37.6–99.0	104/105	99.0	94.8–99.9	1	89
Coronavirus	1/3	33.3	1.7–88.2	106/107	99.1	94.9–99.9	1	91
Influenza B virus	3/3	100	43.9–100	107/107	100	96.5–100	1	89
RSV	4/4	100	51.0–100	106/106	100	96.5–100	0	90
Metapneumovirus	1/1	100	5.1–100	107/107	100	96.5–100	2	90
Parainfluenza virus	1/1	100	5.1–100	106/107	99.1	94.9–99.9	0	92
Adenovirus	0/1	0	0–94.9	107/107	100	96.5–100	0	92
Total	19/23	82.6	62.9–93.0	846/849	99.5	99.0–99.9	9	721
Bacteria
Staphylococcus aureus	22/22	100	85.1–100	156/178	87.6	82.0–91.7	0	0
Haemophilus influenzae	3/3	100	43.9–100	172/197	87.3	81.9–91.3	0	0
Pseudomonas aeruginosa	8/8	100	67.6–100	185/192	96.4	92.7–98.2	0	0
Enterobacter cloacae complex	3/4	75	30.1–98.7	189/196	96.4	92.8–98.3	0	0
Escherichia coli	6/6	100	61.0–100	190/194	97.9	94.8–99.2	0	0
Streptococcus pneumoniae	2/2	100	17.8–100	191/198	96.5	92.9–98.3	0	0
Klebsiella pneumoniae group	4/4	100	51.0–100	192/196	98.0	94.9–99.2	0	0
Streptococcus agalactiae	2/2	100	17.8–100	193/198	97.5	94.2–98.9	0	0
Klebsiella aerogenes	2/2	100	17.8–100	196/198	99.0	96.4–99.8	0	0
Klebsiella oxytoca	3/3	100	43.9–100	196/197	99.5	97.2–99.9	0	0
Moraxella catarrhalis	1/1	100	5.1–100	196/199	98.5	95.7–99.6	0	0
Proteus spp.	0/0	NAe	NA	196/200	98.0	95.0–99.2	0	0
Serratia marcescens	3/3	100	43.9–100	197/197	100	98.1–100	0	0
Acinetobacter baumannii–calcoaceticus complex	0/0	NA	NA	199/200	99.5	97.2–99.9	0	0
Legionella pneumophila	0/0	NA	NA	44/44	100	92.0–100	1	156
Mycoplasma pneumoniae	1/1	100	5.1–100	86/86	100	95.7–100	0	80
Total	60/61	98.4	91.3–99.9	2778/2870	96.8	96.1–97.4	1	236

^aProp., proportion for positive percent agreement (PPA) or negative percent agreement (NPA), calculated as follows: PPA = concordant positive/all positive results by SOC, and NPA = concordant negative/all negative results by SOC.

^bBFPP-pos, SOC-NT, analyte detected by BFPP but not tested by standard of care.

^cSOC testing also detected herpes simplex virus (n = 5), cytomegalovirus (n = 4), Stenotrophomonas maltophilia (n = 4), Acinetobacter spp. (n = 1), Citrobacter freundii complex (n = 1), Klebsiella variicola (n = 1), and Staphylococcus intermedius group (n = 1), which are not included in the BFPP panel. SOC testing detected yeast or mold in an additional 26 samples, including 21 yeasts, 2 Aspergillus spp., 1 Blastomyces dermatitidis/B. gilchristii isolate, 1 Paecilomyces species, and 1 Pneumocystis jirovecii isolate.

^dCI, confidence agreement for a binomial distribution, calculated by the Wilson/Brown method.

^eNA, not applicable.