TABLE 2.
Qualitative detection of bacterial targets between the BioFire PN panel and standard-of-care culturea
| Target | No. of samples |
PPA (CI) | NPA (CI) | |||
|---|---|---|---|---|---|---|
| SOC+ PN+ | SOC+ PN− | SOC− PN+ | SOC− PN− | |||
| A. baumannii complex | 1 | 0 | 0 | 258 | 100 (6–100) | 100 (98–100) |
| E. cloacae complex | 7 | 0 | 4 | 248 | 100 (56–100) | 98.4 (96–99) |
| K. aerogenes | 3 | 0 | 1 | 255 | 100 (31–100) | 99.6 (98–100) |
| E. coli | 1 | 1b | 1 | 254 | 50.0 (3–97) | 99.6 (97–100) |
| H. influenzae | 4 | 0 | 16 | 239 | 100 (40–100) | 93.7 (90–96) |
| K. oxytoca | 2 | 0 | 3 | 254 | 100 (20–100) | 98.8 (96–99) |
| K. pneumoniae group | 8 | 0 | 3 | 248 | 100 (60–100) | 98.8 (96–100) |
| M. catarrhalis | 2 | 0 | 6 | 249 | 100 (20–100) | 96.9 (95–99) |
| Proteus spp. | 2 | 0 | 2 | 254 | 100 (20–100) | 99.2 (97–100) |
| P. aeruginosa | 18 | 1c | 6 | 234 | 94.7 (72–100) | 97.5 (94–99) |
| S. marcescens | 3 | 0 | 0 | 256 | 100 (31–100) | 100 (96–100) |
| S. agalactiae | 1 | 0 | 6 | 253 | 100 (5–100) | 97.6 (94–99) |
| S. pneumoniae | 2 | 0 | 3 | 254 | 100 (20–100) | 98.8 (96–100) |
| S. pyogenes | 0 | 0 | 1 | 258 | ND | 99.6 (98–100) |
| S. aureus | 21 | 1d | 21 | 216 | 95.5 (75–100) | 91.1 (87–94) |
| Total | 75 | 3 | 73 | 3,885 | 96.2 (88–99) | 98.1 (98–99) |
a
SOC, standard-of-care culture; PN, BioFire PN panel; CI, 95% confidence interval; PPA, positive percent agreement; NPA, negative percent agreement.
b
E. coli reported as 1 × 103 in routine culture in addition to 1 × 103 K. pneumoniae and 5 × 104 S. aureus, both of which were detected by the PN panel.
c
P. aeruginosa reported as “few” in routine culture.
d
S. aureus reported at 4 × 103 CFU/ml in routine culture.