FIGURE 4.

TB disease measures and IFNg responses after infectious challenge. (A–C) Total arbitrary score of pathological involvement at endpoint and for lung and extra-thoracic disseminated disease, respectively. (D) Post-mortem enumeration of bacterial burden in the lung. (E–H) PPD-specific and (I–K) ESAT6-CFP10 fusion protein (E6C10) specific IFNg responses by specific ELISPOT analysis of PBMC, at indicated timepoints relative to primary vaccination or infectious challenge. Individual data points are consistently colored according to the Supplementary Table 1; fat horizontal lines indicate group medians.