. 2020 May 26;85:e272–e276. doi: 10.5114/pjr.2020.96010

Table 4.

Disseminated in space (DIS) and disseminated in time (DIT) damage to the nervous system according to the 2017 McDonald criteria

Damage to the central nervous system DIS	Damage to the central nervous system DIT
Minimum one T2 lesion present in at least two typical locations: 1. Paracortical/cortical 2. Periventricular 3. Infratentorial 4. In the spinal cord	Occurrence of new lesions on T2-weighted images and/or contrast-enhanced lesions on a subsequent MRI scan compared to a reference examination, regardless of the time since the baseline examination, or concomitant occurrence of contrast-enhancing and non-enhancing lesions, regardless of the time of this examination in relation to the time of the onset of neurological signs and symptoms (may also be a basic examination), or immunological equivalent of radiological dissemination over time: confirmation of the presence of specific oligoclonal bands (absent in serum) in the cerebrospinal fluid.

Damage to the central nervous system DIS

Damage to the central nervous system DIT

Minimum one T2 lesion present in at least two typical locations:
1. Paracortical/cortical
2. Periventricular
3. Infratentorial
4. In the spinal cord

Occurrence of new lesions on T2-weighted images and/or contrast-enhanced lesions on a subsequent MRI scan compared to a reference examination, regardless of the time since the baseline examination,
or
concomitant occurrence of contrast-enhancing and non-enhancing lesions, regardless of the time of this examination in relation to the time of the onset of neurological signs and symptoms (may also be a basic examination),
or
immunological equivalent of radiological dissemination over time: confirmation of the presence of specific oligoclonal bands (absent in serum) in the cerebrospinal fluid.