Table 2.

Published case reports of HDFN caused by anti-Rh17 alloimmunization: outcome and transfusion therapy of HDFN

Case	Authors [reference], year of publication	Order of pregnancies	HDFN and outcome	Transfusion therapy and other management of HDFN	Source of RBC for fetal and neonatal transfusion
1	De Torregrosa et al. [5], 1961	First	Neonatal jaundice at age 24 h, at the fourth day clinical presentation of neonatal generalized edema and poor general condition; ET was late and neonate died toward the end of the procedure	1 ET after 4 days	Maternal RBCs
		Second	Stillborn fetus in 7th month of pregnancy
2	Badakere and Bhatia [6], 1973	Fifth	Neonatal death within the first 24 h	1 ET (180 mL)	Maternal RBCs
		Sixth	Neonatal death within the first 24 h	1 ET (180 mL)	Maternal RBCs
3	Diao et al. [7], 1990	Third	CS at 36th week of pregnancy; severe anemia and hyperbilirubinemia; after therapy baby is alive and in good health	1 ET, 1 TUT	Incompatible RBCs phenotype ccDEE
4	Mertens et al. [8], 1997	Second	CS in 39th week of pregnancy, severe neonatal anemia and hyperbilirubinemia; after therapy the infant is alive and in good health	1 ET	Compatible thawed RBC (Bank of Frozen Blood)
5	Han et al. [9], 1997	Third	CS, severe anemia (Hb 3.5 g/dL) and fetal hydrops; neonatal death due to generalized hydrops	1 ET, 1 TUT	Incompatible RBCs (ET), maternal RBCs (TUT)
6	Whang et al. [10], 2000	Third	Baby died because of HDFN
		Fourth	CS in 34th week; three plasma exchange therapies during pregnancy before IUTs; after therapy the infant is alive and in good health	3 IUT, 2 ET	Maternal RBCs (IUT), compatible RBCs from relatives (ET)
7	Lenkiewicz and Zupanska [11], 2000	Second	Moderate HDFN	Phototherapy
8	Deitenbeck et al. [12], 2002	Fifth	CS in 34th week	2 IUT, 1 ET, 1 TUT, IVIG	Maternal RBCs frozen before pregnancy
9	Brumit et al. [13], 2002	Second	Moderate HDFN	Phototherapy only
10	Aref et al. [14], 2002	Second	Severe anemia (Hb 6 g/dL) and fetal hydrops, CS at 33rd week of pregnancy, resolution of neonatal hydrops after therapy; correction of duodenal atresia	2 ET, IVIG, erythropoietin	Compatible thawed RBCs
11	Denomme et al. [15], 2004	Second	Delivery at 30th week of pregnancy after premature rupture of membranes; severe anemia (Hb 6 g/dL) and hyperbilirubinemia; baby was discharged from hospital after 1 ET	1 ET	Incompatible O RhD-negative RBCs
		Third	CS due to fetal distress after induction of labor at 38th week of pregnancy; phototherapy was initiated at birth but was discontinued due to low bilirubin levels; follow-up 2 weeks later showed evidence of mild anemia that did not require transfusion	7 IUT, phototherapy	Maternal ABO incompatible RBCs
12	Salamat et al. [16], 2004	Fourth	CS in 8th month of pregnancy; intrauterine death due to fetal hydrops	No
13	Hirose et al. [17], 2004	First; blood transfusion before pregnancy	CS in 34th week, severe anemia and hyperbilirubinemia; after therapy the infant is alive and in good health	1 IUT, 2 ET	Compatible fresh donor's RBCs
14	Shah et al. [18], 2005	Fourth	Delivery in 37th week; after therapy baby is alive and in good health	3 ET, 1 TUT, IVIG	Maternal RBCs (1 ET, 1 TUT); incompatible RBCs (2 ET)
15	Li et al. [26], 2010	Second	Delivery 39th week; neonatal anemia (Hb 8.1 g/dL), severe hyperbilirubinemia and neonatal hydrops; after therapy the infant is alive and in good health	1 ET, 3 TUT, IVIG, phototherapy, methylprednisolone	Incompatible RBCs, donors O RhD-positive phenotype ccEE

HDFN, hemolytic disease of the fetus and newborn; Hb, hemoglobin; IUT, intrauterine transfusion; ET, exchange transfusion; TUT, top-up transfusion; IVIG, intravenous immunoglobulin; CS, cesarean section.