. 2020 Jun 11;5(24):14394–14407. doi: 10.1021/acsomega.0c00934

Table 1. Optimization of the Reaction Conditions^a.

entry	catalyst (mol %)	base (3 equiv)	solvent	temp (°C)	oxidant	yield (%) 3a
1	I₂ (20)		H₂O	rt	air	32
2	I₂ (30)		H₂O	rt	air	38
3	I₂ (40)		H₂O	rt	air	39
4	I₂ (30)		H₂O	50	air	62
5	I₂ (30)		H₂O	60	air	65
6	I₂ (30)		H₂O	70	air	71
7	I₂ (30)		H₂O	80	air	71
8	I₂ (30)	K₂CO₃	H₂O	70	air	94
9	I₂ (30)	NaHCO₃	H₂O	70	air	69
10	I₂ (30)	Na₂CO₃	H₂O	70	air	74
11	I₂ (30)	Cs₂CO₃	H₂O	70	air	trace
12	I₂ (30)	TEA	H₂O	70	air	trace
13	I₂ (30)	DBU	H₂O	70	air	trace
14	I₂ (30)	pyridine	H₂O	70	air	trace
15	I₂ (30)	K₂CO₃	H₂O	70	N₂-atm	0
16		K₂CO₃	H₂O	70	air	0
17	TBAI	K₂CO₃	H₂O	70	air	trace
18	KI	K₂CO₃	H₂O	70	air	trace

Reaction conditions: 1a (0.5 mmol, 1 equiv), 2a (1.0 mmol, 2 equiv), catalyst (0.15 mmol, 0.3 equiv) in solvent (2.0 mL) for 6 h; H₂O = water, rt = room temperature.

Table 1. Optimization of the Reaction Conditionsa.

Table 1. Optimization of the Reaction Conditions^a.