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. Author manuscript; available in PMC: 2021 Apr 8.
Published in final edited form as: J Am Chem Soc. 2020 Mar 25;142(14):6814–6821. doi: 10.1021/jacs.0c02211

Figure 2. Exceptional nuclease resistance of PX DNA.

Figure 2.

(a) Degradation of DNA motifs treated with 0.1 unit of DNase I enzyme. (b, c, d) Degradation of structures treated with RecBCD (exonuclease V), T7 exonuclease and T5 exonuclease, respectively. The known activity of the tested enzymes on duplex DNA is shown as a cartoon in the corresponding figure panels. (e) Activity of different nucleases on PX DNA. (f) Biostability enhancement factor (fold-increase) of PX DNA as compared to duplex and DX. Error bars are standard deviations calculated from experiments performed in triplicates.