Table 3. The association between MTHFR C677T polymorphism with the methylation status of the WIF-1 gene in patients with CRC.
| MTHFR C677T polymorphism | Methylated, n = 28 n (%) |
Unmethylated, n = 22 n(%) |
p-value | OR (95% CI) |
|---|---|---|---|---|
| CC | 22 (78.6) | 6 (27.3) | - | Ref |
| CT | 5 (17.9) | 13 (59.1) | < 0.001 | 9.53 (2.56–40.96) |
| TT | 1 (03.6) | 3 (13.6) | 0.025 | 11 (1.30–14.74) |
| CT+TT vs. CC* | 6 (21.4) | 16 (72.7) | < 0.001 | 9.77 (2.53–34.03) |
| TT vs. CC+ CT** | 1 (03.6) | 3 (13.6) | 0.307 | 4.26 (0.58–57.08) |
| C allele | 49 (87.5) | 25 (56.8) | - | Ref |
| T allele | 7 (12.5) | 19 (43.2) | 0.001 | 5.32 (1.89–13.24) |
*dominant genetic model; **recessive genetic model.
WIF-1: Wnt inhibitory factor-1; CRC: colorectal cancer, OR: odds ratio; CI: confidence interval.