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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Neuropharmacology. 2020 May 23;174:108159. doi: 10.1016/j.neuropharm.2020.108159

Figure 5. Activation of postsynaptic group III mGluRs excites spinally projecting PVN neurons via crosstalk with mGluR5 in SHRs.

Figure 5.

A and B, Original traces (A) and summary data (B) show that blocking G protein signaling with intracellular GDP-β-s eliminated the excitatory effect of L-AP4 on the firing activity in labeled PVN neurons in SHRs (n = 10 neurons from 4 rats). C and D, Original traces (C) and summary data (D) show that DHPG treatment converted the effect of L-AP4 to excitatory in labeled PVN neurons in WKY rats (n = 10 neurons from 4 rats) and SHRs (n = 10 neurons from 4 rats). E and F, Original recording traces (E) and summary data (F) show that MPEP treatment blocked the excitatory effect of L-AP4 on labeled PVN neurons in SHRs (n = 13 neurons from 4 rats). The membrane potential value was shown on the left. G and H, Comparison of mRNA levels of mGluR4 (G) and mGluR6 (H) in the brainstem (BS), frontal cortex (FC), hippocampus (HC), and PVN tissues from 7 WKY rats and 9 SHRs. *P < 0.05 and **P < 0.01, compared with the baseline for the group. #P < 0.05 compared with the value of MPEP alone. ###P < 0.001 compared with WKY rats.