Skip to main content
. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Neuropharmacology. 2020 May 23;174:108159. doi: 10.1016/j.neuropharm.2020.108159

Figure 7. Blocking mGluR5 in the PVN potentiates the inhibitory effect of group III mGluR activation on sympathetic output in SHRs.

Figure 7.

A and B, Original traces show the effects of MPEP (5 nmol, 50 nL) and L-AP4 (10 pmol, 50 nL) microinjected into the PVN on mean blood pressure (ABP), lumbar sympathetic nerve activity (LSNA), and heart rate (HR) in one WKY rat (A) and one SHR (B). C-E, Summary data show the effects of MPEP and L-AP4 microinjected to the PVN on mean ABP, integrated LSNA, and HR in WKY rats (n = 7 rats) and SHRs (n = 8 rats). *P < 0.05 and ***P < 0.001, compared with the baseline for the group. #P < 0.05 and ##P < 0.01, compared with the value of MPEP alone in the same group. F, Representative bright-field and fluorescence images and schematic drawing show the microinjection sites in the PVN in WKY rats (gray) and SHRs (black). 3V, third ventricle.