Figure 1.

Muscadine grape extract (MGE) inhibits tumor growth in vivo. Female nude mice with MDA-MB-231 tumors were treated with 0.1 mg phenolics/mL of MGE for 4 weeks, as shown in the schematic (A). Tumor size was measured at 4 weeks, prior to euthanasia (B). Immunohistological analysis of cyclin D1, which is stained red in the representative images, and Ki67, which is shown as brown with 3,3′-diaminobenzidine (DAB) staining in representative images (C), was quantified (D and E). n = 8; *P < .05, **P < .01, and ***P < .001.