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. 2020 Jun 24;40(6):BSR20201175. doi: 10.1042/BSR20201175

Figure 6. Blockage of EGF or CCL3 can efficiently attenuate the bone resorption in bone metastasis of CRC.

Figure 6

(A) Safranin O-Fast Green staining showing the trabecular area and Trap analysis showing the number of Trap (+) cells in bone metastasis of CRC after treated with EGF neutralizing antibody at 21 days after intratibially injection of MC-38 cells (scale bar = 100 μm). (B) Quantification of trabecular area from Safranin O-Fast green staining in (A). (C) Quantification of osteoclast number in (A). (D) Safranin O-Fast Green staining showing the trabecular area and Trap analysis showing the number of Trap (+) cells in bone metastasis of CRC after treated with CCL3 neutralizing antibody at 21 days after intratibially injection of MC-38 cells (scale bar = 100 μm). (E) Quantification of trabecular area from Safranin O-Fast green staining in (D). (F) Quantification of osteoclast number in (D). Abbreviations: nAb, neutralizing antibody; Ctrl, control; No., number. *P<0.05, **P<0.01, ***P<0.001.